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Annals of Clinical & Laboratory Science 32:257-263 (2002)
© 2002 Association of Clinical Scientists

Nitric Oxide Production Increases during Normal Pregnancy and Decreases in Preeclampsia

Jong Weon Choi1, Moon Whan Im2 and Soo Hwan Pai1
1 Department of Clinical Pathology and 2 Department of Obstetrics, Inha University College of Medicine, Inchon, Korea

Address correspondence to Soo Hwan Pai, M.D., Department of Clinical Pathology, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon, 400-103, Korea; tel 82 32 890 2502; fax 82 32 890 2529; e-mail shpaimd{at}inha.ac.kr.

To investigate the changes in nitric oxide (NO) production during and after normal pregnancy and in pregnancies complicated by preeclampsia, we measured serum nitrates and nitrites (NOx) concentrations and serum iron markers in 347 subjects. Serum NOx concentrations were determined after reduction of nitrates to nitrites using the Griess reaction. Serum iron and serum ferritin were assayed using an automatic chemical analyzer and a chemiluminescence method. Serum NOx concentrations were significantly higher in the first trimester (117.3 ± 31.4 µM) than in nonpregnant women (23.8 ± 7.1 µM). High NOx concentrations persisted throughout normal pregnancy, irrespective of serum ferritin concentrations, and returned to nonpregnant levels by 9–12 wk postpartum. Mean NOx concentrations in preeclamptic women were 43.1 ± 12.7 µM, which were significantly lower than those in the gestation age-matched normal pregnant women (249.7 ± 51.3 µM). In summary, NO production increases with advancing gestation during normal pregnancy and decreases in preeclampsia, regardless of serum ferritin concentrations. Elevated NOx concentrations during pregnancy return to normal within 12 wk after delivery.

Keywords: nitric oxide, pregnancy, preeclampsia, ferritin, iron




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