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Ultrastructural Comparison of "Alveolar" and "Solid" Areas in Bronchioloalveolar Carcinoma

Address correspondence to Steven I. Hajdu, M.D., Department of Surgical Pathology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA; tel 516 562 4180; fax 516 562 4591.

The purpose of this study was to compare the ultrastructural features of bronchioloalveolar carcinomas, contrasting the well-differentiated alveolar component and the poorly-differentiated solid component in the same tumor. We studied 7 cases of non-mucinous bronchioloalveolar carcinomas by electron microscopy. Two of these cases showed lamellar bodies in both the alveolar and solid components and the remaining 5 cases revealed Clara cell granules in both components. We conclude that the neoplastic cells in bronchioloalveolar carcinoma retain their ultrastructural phenotypes after becoming invasive carcinoma with loss of alveolar differentiation.

Keywords: bronchioloalveolar carcinoma, electron microscopy, lamellar bodies, Clara cell granules

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