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Annals of Clinical & Laboratory Science 31:253-258 (2001)
© 2001 Association of Clinical Scientists

Serum Anti-p53 Autoantibodies in Patients with Type 1 Diabetes

Enrico Di Cesare1, Marcello Previti1, Fortunato Lombardo2, Antonino Di Benedetto1, Nicola Mazzù1, Giacomo Romano1, Filippo De Luca2, Antonio Lasco1 and Domenico Cucinotta2
1 Department of Internal Medicine and 2 Institute of Paediatrics, University of Messina, Messina, Italy.

Address correspondence to Enrico Di Cesare, M.D., Via San Camillo no. 8, 98122 Messina, Italy; tel 39 090 293 6528; fax 39 090 292 1554; email domenico.cucinotta{at}unime.it.

The presence of antibodies reacting with the p53 tumor suppressor protein has been described in patients with some autoimmune disorders. In this study we looked for serum anti-p53 antibodies in 64 patients with autoimmune type 1 diabetes mellitus within 4 mo of diagnosis. The presence of anti-p53 antibodies was observed in 6/64 (9.4% ) subjects with type 1 diabetes, and in 1/44 (2.3%) subjects with other organ-specific autoimmune diseases (18 primary biliary cirrhosis, 10 autoimmune hepatitis, 16 thyroid diseases), but in none of 45 control subjects. No relationship was found between antibodies directed against islet- and non-islet-specific antigens and anti-p53 antibodies. These findings support a possible role for p53 in some autoimmune disorders.

Keywords: anti-p53 antibodies, type 1 diabetes, autoimmune diseases






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