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Annals of Clinical & Laboratory Science 31:245-252 (2001)
© 2001 Association of Clinical Scientists

Nuclear Localization of Thyroid Transcription Factor-1 Correlates with Serum Thyrotropin Activity and May Be Increased in Differentiated Thyroid Carcinomas with Aggressive Clinical Course

Cydney L. Fenton1,4, Aneeta Patel2, Henry B. Burch3, R. Michael Tuttle5 and Gary L. Francis1,4
Departments of Pediatrics,1 Clinical Investigation,2 and Medicine,3 Walter Reed Army Medical Center, Washington, District of Columbia; 4 Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; and 5 Department of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or to reflect the opinions of the Uniformed Services University of the Health Sciences, the Department of the Army, or the Department of Defense. Address correspondence to Gary L. Francis, M.D., Ph.D., Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA; tel 301 295 9716; fax 301 295 3898; e-mail gfrancis{at}usuhs.mil.

Thyroid transcription factor 1 (TTF-1) is essential for thyroid differentiation and regulates expression of thyroglobulin, thyroid peroxidase, sodium/iodide symporter, and thyrotropin receptor (TSH-R) genes. Because thyrotropin (TSH) upregulates these same genes, we hypothesized TSH-R activation might increase TTF-1 and that TTF-1 might be differentially expressed in benign and malignant thyroid disease. TTF-1 expression and sub-cellular localization were determined by immunohistochemistry in 62 thyroid carcinomas, 15 benign lesions, and 2 normal thyroids. Nuclear TTF-1 was detected in benign (77%) and malignant lesions (69%), with similar intensity in both (1.1 ± 0.19 versus 1.0 ± 0.10). Nuclear TTF-1 staining correlated with the effective serum TSH level (p = 0.02) and patient age (p < 0.05). Nuclear TTF-1 was detected in 35 papillary thyroid carcinomas (PTC), of which 23% developed recurrent or persistent disease, and was absent from 18 PTC, of which only 6% recurred (p = 0.06). We conclude that nuclear TTF-1 correlates with serum TSH activity, increases with age, and may be increased in persistent or recurrent PTC.

Keywords: Thyroid transcription factor (TTF-1), thyrotropin (TSH), thyroid cancer, immunohistochemistry




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 Annals of Clinical & Laboratory ScienceHome page
T. G. Eccles, A. Patel, A. Verma, D. Nicholson, Y. Lukes, R. M. Tuttle, and G. L. Francis
Erythropoietin and the Erythropoietin Receptor Are Expressed by Papillary Thyroid Carcinoma fromChildren and Adolescents.: Expression of Erythropoietin Receptor Might Be a Favorable Prognostic Indicator
Ann. Clin. Lab. Sci., October 1, 2003; 33(4): 411 - 422.
[Abstract] [Full Text] [PDF]


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