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Annals of Clinical & Laboratory Science 31:103-107 (2001)
© 2001 Association of Clinical Scientists

Scabies Associated with Radiation Therapy for Cutaneous T-Cell Lymphoma

Douglas H. McGregor1, Qinghua Yang1, Fang Fan1, Robert L. Talley2 and Margarita Topalovski1
1 Department of Pathology and Laboratory Medicine, and 2 Department of Medicine, Veterans Affairs Medical Center, Kansas City, Missouri, and University of Kansas Medical Center, Kansas City, Kansas.

Address correspondence to Douglas H. McGregor, MD, Pathology and Laboratory Medicine (DRC/113), Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA; tel 816 922 2406; fax 816 922 3306; e-mail mcgregor.d.{at}kansas-city.va.gov.

Scabies, infection with Sarcoptes scabiei, is known to be predisposed to by poor body hygiene, environmental exposure, and systemic immunodeficiency. We report the case of an 83-year-old man with Sezary’s syndrome who developed scabies limited to the skin of the upper chest, the same location where he had previously received electron beam radiation treatments for cutaneous T-cell lymphoma. Histologic and immunohistochemical studies demonstrated that sections of the previously irradiated right and left chest skin, compared to non-irradiated chest, abdominal, and leg skin, had infestation by scabies, diminished involvement by T-cell lymphoma, and notably reduced numbers of Langerhans cells. These findings suggest that the development of scabies may be predisposed to by local cutaneous radiation therapy, and that it may be mediated by local cutaneous immunodeficiency secondary to reduced numbers of Langerhans cells.

Keywords: Scabies, radiation, Langerhans cells, immunodeficiency, cutaneous T-cell lymphoma




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