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Annals of Clinical and Laboratory Science, Vol 28, Issue 1, 43-50
Copyright © 1998 by Association of Clinical Scientists

Articles

Effects of metallic antioxidants on cadmium-catalyzed peroxidation of arachidonic acid

SJ Yiin and TH Lin

In the present study, the reaction mixtures (cadmium chloride with arachidonic acid) were preincubated at 37 degrees C for 24 h prior to the measurement of malondialdehyde (MDA) by high performance liquid chromatography (HPLC). The cadmium-catalyzed reactions were also compared to those in the presence of selenium (Se), zinc (Zn) or germanium (Ge), metallic antioxidants. Our results showed that the toxic effects of cadmium cause lipid peroxidation of arachidonic acid by the catalytic process. The addition of metallic antioxidants to the reaction mixtures, might be useful in protecting against Cd-induced lipid peroxidation.




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Copyright © 1998 by the Association of Clinical Scientists.