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Annals of Clinical and Laboratory Science, Vol 26, Issue 2, 114-118
Copyright © 1996 by Association of Clinical Scientists

Articles

Chemiluminescent detection of gene rearrangements in hematologic malignancy

KA Hodges, CM Kosciol, WN Rezuke, EC Abernathy, WT Pastuszak, and GJ Tsongalis

A chemiluminescent based Southern blot assay is described for the detection of gene rearrangements in human hematologic malignancies. The DNA probes for regions of rearrangements within the immunoglobulin genes were labeled with digoxigenin-11-dUTP and detected by an antibody conjugated to alkaline phosphatase with Lumiphos 530 as a substrate. This assay has proven more sensitive than colorimetric assays and provides rapid turn-around times without the hazards of radioactive isotopes.


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W. N. Rezuke, E. C. Abernathy, and G. J. Tsongalis
Molecular diagnosis of B- and T-cell lymphomas: fundamental principles and clinical applications
Clin. Chem., October 1, 1997; 43(10): 1814 - 1823.
[Abstract] [Full Text] [PDF]


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