Annals of Clinical and Laboratory Science, Vol 24, Issue 1, 22-26
Copyright © 1994 by Association of Clinical Scientists
Long-term oral administration of aluminum in mice. Aluminum distribution in tissues and effects on calcium metabolism
LJ Anghileri,
P Maincent,
and
P Thouvenot
Six months of oral administration of aluminum lactate provokes an important accumulation of aluminum in various tissues of mice. The accumulation magnitude order is spleen > kidney > brain > liver > blood. No systemic toxic effects (weight loss or neurolytic effects) were observed. Values of calcium content and 45Ca-uptake by the different tissues showed no modifications of calcium metabolism. The lack of calcium homeostasis modification caused by a probable aluminum insolubilization, and the incidence of other individual factors on individual deviations from group behavior is discussed.