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Annals of Clinical and Laboratory Science, Vol 24, Issue 1, 22-26
Copyright © 1994 by Association of Clinical Scientists


Articles

Long-term oral administration of aluminum in mice. Aluminum distribution in tissues and effects on calcium metabolism

LJ Anghileri, P Maincent, and P Thouvenot

Six months of oral administration of aluminum lactate provokes an important accumulation of aluminum in various tissues of mice. The accumulation magnitude order is spleen > kidney > brain > liver > blood. No systemic toxic effects (weight loss or neurolytic effects) were observed. Values of calcium content and 45Ca-uptake by the different tissues showed no modifications of calcium metabolism. The lack of calcium homeostasis modification caused by a probable aluminum insolubilization, and the incidence of other individual factors on individual deviations from group behavior is discussed.





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Copyright © 1994 by the Association of Clinical Scientists.