Annals of Clinical and Laboratory Science, Vol 22, Issue 6, 414-416
Copyright © 1992 by Association of Clinical Scientists
Hemoglobin C--G-Georgia double heterozygosity: a case report
S Reynolds,
C Miller,
R King,
and
J Lazarchick
A 12-month-old black female with an unremarkable past medical history was admitted to the hospital with respiratory distress and fever without identified sepsis. Despite mechanical ventilation, the patient died as a result of respiratory insufficiency secondary to severe necrotizing bronchitis and bronchiolitis with pneumonia. Electrophoretic and biochemical analyses of the patient's hemoglobin showed the patient to be a double heterozygote for hemoglobin C (a beta chain variant) and hemoglobin G-Georgia (an alpha chain variant). This is the first report of this combination of hemoglobin variants.