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Annals of Clinical and Laboratory Science, Vol 22, Issue 6, 414-416
Copyright © 1992 by Association of Clinical Scientists


Articles

Hemoglobin C--G-Georgia double heterozygosity: a case report

S Reynolds, C Miller, R King, and J Lazarchick

A 12-month-old black female with an unremarkable past medical history was admitted to the hospital with respiratory distress and fever without identified sepsis. Despite mechanical ventilation, the patient died as a result of respiratory insufficiency secondary to severe necrotizing bronchitis and bronchiolitis with pneumonia. Electrophoretic and biochemical analyses of the patient's hemoglobin showed the patient to be a double heterozygote for hemoglobin C (a beta chain variant) and hemoglobin G-Georgia (an alpha chain variant). This is the first report of this combination of hemoglobin variants.





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Copyright © 1992 by the Association of Clinical Scientists.