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Annals of Clinical and Laboratory Science, Vol 21, Issue 1, 36-39
Copyright © 1991 by Association of Clinical Scientists

Articles

The anatomic basis of maternal serum screening

RW Bendon

Fetal serum markers, such as alpha fetoprotein (AFP), must traverse one of two very different pathways to reach maternal serum, either from fetus to amnion fluid, membranes and decidua or from fetal to maternal circulation through the placental villi. Alpha fetoprotein usually enters the amnion fluid through body wall defects uncovered by skin or through urine. Placental AFP leakage may be from villous hemorrhage or injury. These observations from anatomic pathology suggest that biochemical markers may exist to identify the source of elevated maternal serum AFP.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Brownbill, D. Mahendran, D. Owen, P. Swanson, K. L. Thornburg, D. M. Nelson, and C. P. Sibley
Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytiotrophoblast
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R677 - R683.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by the Association of Clinical Scientists.