Annals of Clinical and Laboratory Science, Vol 19, Issue 3, 196-207
Copyright © 1989 by Association of Clinical Scientists
Strategy for purification of coagulation factor concentrates
DB Clark,
WN Drohan,
SI Miekka,
and
AJ Katz
Advances in biotechnology are permitting significant changes in traditional plasma fractionation schemes. Increases in product purity, safety, and recovery are possible, and new products are being developed. Applications of technology to the purification of factor IX, factor X, protein C, antithrombin III, thrombin, and fibrin glue are described.