ACLS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, D.
Annals of Clinical and Laboratory Science, Vol 18, Issue 5, 388-397
Copyright © 1988 by Association of Clinical Scientists

Articles

Characterization of the biological activity of Cryptococcus infections in surgical pathology. The Budding Index and Carminophilic Index

DA Schwartz

The histologic spectrum of cryptococcosis varies greatly, including florid granulomatous reactions, necrotizing infections, fibrotic nodules or "cryptococcomas", and gelatinous reactions containing scant or absent inflammatory cells. These variants are thought to represent differences both in the duration and activity of the infection as well as the nature and extent of the immune response. However, there exists no method for the quantitation of these factors in tissue sections to form an estimate of the activity of the infection. This communication reviews 16 cases of cryptococcosis and describes a method for the estimation of the biological activity of cryptococcosis in tissue sections by determination of the percentage of budding organisms (Budding Index) and yeasts having carminophilic capsules (Carminophilic Index). These indices may be useful for the assessment of cryptococcal viability and divisional activity within a lesion, as well as estimation of the fungistatic or fungicidal effects of therapy.


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
E. E. B. Ghosn, M. Russo, and S. R. Almeida
Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte
J. Leukoc. Biol., July 1, 2006; 80(1): 36 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Feldmesser, A. Mednick, and A. Casadevall
Antibody-Mediated Protection in Murine Cryptococcus neoformans Infection Is Associated with Pleotrophic Effects on Cytokine and Leukocyte Responses
Infect. Immun., March 1, 2002; 70(3): 1571 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Feldmesser, Y. Kress, P. Novikoff, and A. Casadevall
Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection
Infect. Immun., July 1, 2000; 68(7): 4225 - 4237.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
L.-C. Chen and A. Casadevall
Variants of a Cryptococcus neoformans Strain Elicit Different Inflammatory Responses in Mice
Clin. Vaccine Immunol., March 1, 1999; 6(2): 266 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. N. Steenbergen, H. A. Shuman, and A. Casadevall
From the Cover: Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages
PNAS, December 18, 2001; 98(26): 15245 - 15250.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the Association of Clinical Scientists.