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Annals of Clinical and Laboratory Science, Vol 17, Issue 5, 324-330
Copyright © 1987 by Association of Clinical Scientists

Articles

Neuropeptide modulation of murine erythropoiesis

RR Skelly, J Fata, SJ Sharkis, L Sensenbrenner, and AA Ansari

Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells.




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Copyright © 1987 by the Association of Clinical Scientists.