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Annals of Clinical and Laboratory Science, Vol 16, Issue 2, 130-133
Copyright © 1986 by Association of Clinical Scientists

Articles

Effect of profound hypothermia on leukocytes and platelets

SA Shenaq, DH Yawn, A Saleem, R Joswiak, and ES Crawford

Seventeen patients who underwent aortic arch replacement were subjected to profound hypothermia and circulatory arrest. At maximum cooling, platelet count dropped from 184 +/- 122 to 37 +/- 30 thousand per microliter, and the total leukocytic count fell from 6.27 +/- 4.0 to 1.47 +/- 0.6 thousand per microliter. The thrombocytopenia was partially reversed with rewarming. The total white cell count consistently returned to precooling values or higher (10.5 +/- 4.0). The mechanism for this cold induced phenomenon is not well understood.


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