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Annals of Clinical and Laboratory Science, Vol 15, Issue 5, 414-417
Copyright © 1985 by Association of Clinical Scientists

Articles

Immunohistochemical demonstration of human chorionic gonadotropin in tumors of the urinary bladder

HT Yamase, RS Wurzel, PT Nieh, and B Gondos

All transitional cell carcinomas of the bladder diagnosed in male patients within a five year period were studied for human chorionic gonadotropin (hCG) production. Biotin-avidin immunoperoxidase analysis for hCG was performed on all paraffin blocks containing carcinoma-in-situ, grade I, grade II, and grade III transitional cell carcinoma. Of a total of 29 patients, one case of carcinoma-in-situ (1/5), and five cases of grade III transitional cell carcinoma (5/15) were found to have hCG-positive tumor cells. The findings indicate that transitional cell carcinoma should be added to the list of malignant tumors capable of producing hCG.




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Copyright © 1985 by the Association of Clinical Scientists.