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Annals of Clinical and Laboratory Science, Vol 15, Issue 5, 400-405
Copyright © 1985 by Association of Clinical Scientists

Articles

Optimization and evaluation of cardiac enzymes and isoenzymes measured on a random access analyzer

J Savory, RG Stallings, DE Bruns, MG Savory, M Margrey, and JC Boyd

Four serum enzymes and isoenzymes used in the diagnosis of acute myocardial infarction (AMI), lactate dehydrogenase LD and LD-1, creatine kinase (CK), and CK-MB have been adapted to the Technicon RA-1000 automated clinical chemistry analyzer. Analytical parameters have been adjusted to provide clinically acceptable precision for all four assays. Correlations with centrifugal analyzer procedures gave correlation coefficients ranging from 0.998 to 0.999. A limited clinical study of the CK-MB assay indicated that a discriminant value of 13 U per L could separate AMI from non-AMI patients.




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Copyright © 1985 by the Association of Clinical Scientists.