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Annals of Clinical and Laboratory Science, Vol 13, Issue 4, 289-290
Copyright © 1983 by Association of Clinical Scientists

Articles

Topographical distribution of dimethylbenz(a)anthracene-induced rat mammary tumors

JA Kellen

Intravenous administration of dimethylbenz(a)anthracene (DMBA) in the rat induces multiple mammary tumors. The nodules, benign or malignant, develop preferentially in the thoracic part of the milk line. Actinomycin D interferes with the carcinogenic action of DMBA, but it does not alter the regional distribution of the tumors formed. Evaluation of experimental data, using this tumor model, should take tumor topography into consideration.




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Copyright © 1983 by the Association of Clinical Scientists.