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Annals of Clinical and Laboratory Science, Vol 12, Issue 5, 403-407
Copyright © 1982 by Association of Clinical Scientists

Articles

Terminal deoxynucleotidyl transferase activity in non-hematologic and hematologic neoplasms

A Castella, FR Davey, AS Kurec, and NA Thompson

The presence of terminal deoxynucleotidyl transferase (TdT) has been determined in neoplastic cells from 50 patients with non-hematologic tumors as well as neoplastic cells from 85 patients with hematologic malignancies. The results indicate that TdT is not present in cells from non-hematologic tumors, Hodgkin's lymphoma, B cell lymphoproliferative disorders, peripheral T cell neoplasms, reactive lymphadenopathy, and acute non-lymphocytic leukemia. In contrast, TdT activity is present in non-T non-B cell acute lymphocytic leukemia, T cell acute lymphocytic leukemia, T cell lymphoblastic lymphoma and chronic granulocytic leukemia in blast crisis. It is concluded that the TdT assay is a measurement useful in the differential diagnosis of some hematologic malignancies.




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Copyright © 1982 by the Association of Clinical Scientists.