Preliminary use of linear discriminant function to predict success or failure of kidney transplant

Adenylate kinase (AK) activity appears in serum or in urine as a result of tissue destruction. The serum and urine AK activity are normally very low (as previously reported). These studies were carried out to determine the usefulness of measuring the appearance of urinary AK activity in the detection of renal transplant crisis. Serum creatinine determinations, the results of nuclear medicine studies and other clinical evidence, were compared with urinary AK activity during renal transplant crises. As a result of these studies, a model is proposed which assesses the reliability of predictors of success or failure of kidney transplants by step-wise discriminant function analysis using adenylate kinase and creatinine clearance measurements of urine to separate patients into two groups based on whether the kidney transplant was removed or retained postoperatively. The effectiveness of the predictors used in the analyses changed with respect to their importance during nonhomogeneous time intervals of analysis.