Hemoglobin A1c and diabetes mellitus

HbA1 is the result of the non-enzymatic glycosylation of HbA. HbA1 reflects the integrated blood glucose level that prevailed over a period of weeks; it thus has clinical application in the assessment of the long-term blood glucose control. This ability to determine easily the long-term blood glucose should enable the clinical investigator to gain insights into the relationship of glycemia and the complications resulting from long-standing diabetes mellitus.