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Annals of Clinical and Laboratory Science, Vol 10, Issue 1, 9-12
Copyright © 1980 by Association of Clinical Scientists

Articles

Lymphocyte blast transformation and peripheral lymphocyte percentages in patients with sickle cell disease

AB Glassman, DV Deas, FS Berlinsky, and CE Bennett

Twenty patients with sickle cell disease (14 black females and 6 black males, mean age 31.5 +/- 9.3) were studied by quantitating peripheral T and B lymphocyte percentages and measuring lymphocyte blast transformation (LBT) in response to phytohemagglutinin-P, concanavalin-A and pokeweed mitogen. Compared to normal black controls (19 black females and 1 black male, mean age 32.0 +/- 9.2 years) sickle cell patients had decreased T lymphocytes (50.2 percent +/- 6.2 compare; to 66.2 percent +/- 1.7) and increased B lymphocytes (17.0 percent +/- 3.4 compared to 7.7 percent +/- 1.1). Sickle patients exhibited decreased LBT to all three mitogens.




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Copyright © 1980 by the Association of Clinical Scientists.